Notice: Function _load_textdomain_just_in_time was called incorrectly. Translation loading for the mpc domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 6121

Deprecated: Creation of dynamic property MPC_WC_Grid_Products::$default_atts is deprecated in /var/www/vhosts/mycbds.co.uk/public_html/wp-content/plugins/mpc-massive/shortcodes/mpc_wc_grid_products/mpc_wc_grid_products.php on line 27

Notice: Function _load_textdomain_just_in_time was called incorrectly. Translation loading for the viva-wallet-for-woocommerce domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 6121

Notice: Function WP_Scripts::localize was called incorrectly. The $l10n parameter must be an array. To pass arbitrary data to scripts, use the wp_add_inline_script() function instead. Please see Debugging in WordPress for more information. (This message was added in version 5.7.0.) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 6121

Notice: Function WP_Scripts::localize was called incorrectly. The $l10n parameter must be an array. To pass arbitrary data to scripts, use the wp_add_inline_script() function instead. Please see Debugging in WordPress for more information. (This message was added in version 5.7.0.) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 6121

Notice: Function WP_Scripts::localize was called incorrectly. The $l10n parameter must be an array. To pass arbitrary data to scripts, use the wp_add_inline_script() function instead. Please see Debugging in WordPress for more information. (This message was added in version 5.7.0.) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 6121

Notice: Function WP_Scripts::localize was called incorrectly. The $l10n parameter must be an array. To pass arbitrary data to scripts, use the wp_add_inline_script() function instead. Please see Debugging in WordPress for more information. (This message was added in version 5.7.0.) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 6121
nervous system

Tag: nervous system

  • What’s The Difference Between Non-Intoxicating CBD & THC

    What’s The Difference Between Non-Intoxicating CBD & THC


    Deprecated: mb_convert_encoding(): Handling HTML entities via mbstring is deprecated; use htmlspecialchars, htmlentities, or mb_encode_numericentity/mb_decode_numericentity instead in /var/www/vhosts/mycbds.co.uk/public_html/wp-content/plugins/mpc-massive/shortcodes/mpc_snippets.php on line 2300

    Why is THC intoxicating and CBD is not? How can one cannabinoid alter the mind, & the other not at all?

    When we’re talking about cannabis and euphoria, we’re dealing exclusively with CB1 receptors, which are concentrated in the brain and the central nervous system. The difference between CBD vs. THC comes down to a basic difference in how each one interacts with the cannabinoid 1 (CB1) receptor. THC binds well with CB1 cannabinoid receptors. CBD has a low binding affinity for CB1 receptors. That’s where the two diverge.

    Think of it like an electrical plug connecting to a wall socket. A THC molecule is perfectly shaped to connect with CB1 receptors. When that connection happens, THC activates or stimulates those CB1 receptors. Researchers call THC a CB1 receptor agonist, which means THC works to activate those CB1 receptors.

    THC partially mimics a naturally produced neurotransmitter known as anandamide, aka “the bliss molecule.” Anandamide is an endocannabinoid which activates CB1 receptors. Animal studies have taught us that anandamide can increase appetite and enhance pleasure associated with food consumption, and it’s likely responsible for some of the rewarding effects of exercise (e.g. the “runner’s high”). Anandamide also plays a role in memory, motivation, and pain. THC is a “key” that so closely resembles anandamide that it activates CB1 receptors, allowing it to produce some of those same blissful feelings.

    CBD, by contrast, is not a good fit with CB1 receptors. It’s categorized as an antagonist of CB1 agonists. This means that it doesn’t act directly to activate or suppress CB1 receptors—rather, it acts to suppress the CB1-activating qualities of a cannabinoid like THC. In other words, when you ingest THC and CBD, the THC directly stimulates those CB1 receptors, while the CBD acts as a kind of modulating influence on the THC. As Project CBD co-founder Martin Lee once wrote: “CBD opposes the action of THC at the CB1 receptor, thereby muting the psychoactive effects of THC.”


    Deprecated: mb_convert_encoding(): Handling HTML entities via mbstring is deprecated; use htmlspecialchars, htmlentities, or mb_encode_numericentity/mb_decode_numericentity instead in /var/www/vhosts/mycbds.co.uk/public_html/wp-content/plugins/mpc-massive/shortcodes/mpc_snippets.php on line 2300
    ArticleCBDvsTHC 1024x813 1
    Left: THC directly stimulates the CB1 receptor. This interaction underlies the major psychoactive effects of Cannabis consumption. Right: CBD reduces, or “antagonizes,” THC’s ability to stimulate CB1 receptors. This can decrease some of THC’s effects, especially negative effects like anxiety and short-term memory impairment.

    How does that work in real life? Let’s say you vaporize cannabis flower with 24 percent THC. If that flower has 0.2 percent CBD, the THC is going to excite your CB1 receptors with almost no interference from CBD. You may feel extremely high, and you might also experience some of the less desirable effects of THC, such as a heightened feeling of paranoia. If you consume cannabis with 24 percent THC and 6 percent CBD, though, the CBD should have a dampening effect on the THC. You’ll still feel high, but perhaps not stupefyingly so—and the CBD should help keep the paranoia in check.

    This difference has had profound political implications. As the founders of Project CBD have noted, some have mistakenly labelled THC the “bad cannabinoid” and CBD the “good cannabinoid.” Legislators have passed many “CBD-only” laws in Southern states in an effort to allow patients access to this potent cannabinoid while prohibiting its euphoric sibling. But the pioneering cannabis researcher Raphael Mechoulam has often spoken of the “entourage effect,” the idea that cannabinoids and terpenes may work better together than in isolation. The GW Pharma product Sativex, for example, is a drug approved outside the U.S. for treatment of MS-related muscle spasticity. Sativex contains with a nearly 1:1 CBD-to-THC ratio.

    As researchers learn more about CBD and the role of other cannabinoids and compounds in the treatment of conditions like MS, we may be able to more accurately dose CBD in combination with other cannabis-derived compounds.

    Reference: Leafly

  • Everything You Need To Know About Using CBD

    Everything You Need To Know About Using CBD


    Deprecated: mb_convert_encoding(): Handling HTML entities via mbstring is deprecated; use htmlspecialchars, htmlentities, or mb_encode_numericentity/mb_decode_numericentity instead in /var/www/vhosts/mycbds.co.uk/public_html/wp-content/plugins/mpc-massive/shortcodes/mpc_snippets.php on line 2300

    The compound, found in the cannabis plant, is thought to be good for muscle pain, headaches and anxiety, among other things. But what does the research say?

    James Joliat, a 35-year-old video producer in Denver, has long experienced muscle and joint pain—mostly related to sports injuries. He says he started looking at natural remedies as an alternative to the prescription patches and pills his doctor recommended. After experimenting with homemade rubs infused with plant compounds—stuff like arnica and turmeric—he eventually stumbled onto topical cannabidiol (CBD) rubs.

    “I put that on my ankle after hiking or on my lower back, and it just feels like it really penetrates and has good anti-inflammatory properties,” he says. “I also fucked up my shoulder, and I felt like it helped a lot with the pain.”

    He’s been using topical CBD for years with good results, and he recently tried ingesting CBD oil, which he called an “amazing” experience. “I just felt super relaxed—kind of an anti-anxiety type of feeling,” he says. “My body felt super mellow and limber, but not in a tired kind of way.”

    “I just felt good,” he adds. “But I wasn’t high at all.” Joliat’s anecdotal experience with CBD is a common one. Some informal polling suggests a lot of people today are at least vaguely familiar with cannabidiol and have either used it themselves or know someone who has. But even some people who use it don’t seem to know exactly what it is or whether there’s any hard science out there to back up its benefits.

    What Is CBD?

    “Cannabidiol is a compound found in the cannabis plant,” says Jerzy Szaflarski, a professor of neurology and director of the Division of Epilepsy at the University of Alabama, Birmingham.

    Szaflarski explains that cannabis contains about 500 different compounds, some of which—including CBD and THC—interact with certain chemical receptors in the human nervous system. But unlike THC, CBD isn’t psychoactive—meaning it doesn’t cause any kind of a high. Despite that, the US Drug Enforcement Agency classifies CBD (and other cannabis compounds) as schedule I substances, making their sale illegal in many states.

    “The brain has these receptors that respond to endocannabinoids, which are neurotransmitters that are naturally produced in the body and brain,” says Jerald Simmons, a neurologist at Houston’s Comprehensive Sleep Medicine Associates. “Some of the cannabinoids in the marijuana plant are very similar to the endocannabinoids in the brain, and they act on the same receptors.”

    The nervous system’s endocannabinoid system is not well understood. But it’s thought to play a role in regulating pain, sleep, mood, memory, appetite, and other cognitive and physical processes. Because CBD is able to mimic the actions of some natural brain chemicals, its potential therapeutic benefits are wide-ranging but—at this point—nebulous. “We know that cannabidiol modulates the endocannabinoid system, but we don’t know how it works,” Szaflarski says. That said, there are theories.

    “THC”—the more-famous, high-inducing compound in cannabis—“works directly on the cannabinoid system, meaning it attaches to receptors and mimics some of our own internal endocannabinoids,” says Igor Grant, a professor and chair of psychiatry at the University of California, San Diego School of Medicine. But CBD’s interaction with the endocannabinoid system is subtler. “Normally, these endocannabinoid-signaling molecules are broken down by enzymes, and one thing CBD does is interfere with the actions of those enzymes.”

    Grant says this may lead to a “dampening” or mellowing of some neurochemical processes, including those linked to pain. “CBD may also react with other receptors, like those for serotonin, and it may have actions that reduce the inflammatory molecules produced whenever there is tissue damage or bacteria coming in,” he says. “But we really don’t know the mechanisms.”

    Should I take CBD to treat pain?

    Talk to people or spend time on internet message boards, and you’ll see CBD is thought to have anti-pain, anti-soreness, and anti-inflammatory benefits. Some rat studies have linked topical CBD treatments to a drop in arthritis-related pain and swelling, and more research suggests it could help relieve headaches.

    That headache study cites research linking CBD to lower rates of anxiety. (Since anxiety often produces headaches, the authors say, CBD could be a plausible headache remedy if those anti-anxiety benefits are legit.) Grant says he’s looked at the literature on CBD and anxiety, and some of it is enticing. He mentions a Brazilian study, for instance, that found people with a fear of public speaking felt less anxiety and less discomfort about their phobia after taking CBD, compared to those who took a placebo.

    “There’s also some evidence it reduces psychotic symptoms in people with schizophrenia and psychotic disorders,” Grant says. “But there are a lot of open questions at this point.”

    One area where CBD is clearly helpful: the treatment of seizures associated with one form of epilepsy. A 2017 New England Journal of Medicine study found ingesting oral CBD dramatically cut down most patients’ seizure frequency—a finding that prompted the FDA to support the approval of one CBD drug for use in the treatment of some epilepsy patients.

    How do people take CBD?

    It’s usually sold as a droplet-administered oil or a balm, but it’s also sold in caplets, under-the-tongue tabs, lotions, face serums, and other products.

    Some users speculate about appropriate dosages or methods of application—including whether or not a small amount of THC boosts CBD’s effects, or whether different methods of administration lead to quicker or more significant effects. Some CBD producers also claim that it has a cumulative effect, and so needs to be used regularly to produce a benefit. But Grant says it’s tough to say at this point exactly how people should (or shouldn’t) be using CBD.

    “Even where marijuana is legal, you often don’t know exactly what you’re getting,” he says. “I’m sure some of these [CBD] producers have labs and do correct labelling, but none of it’s secure like it is with pharmaceuticals.”

    The nutrition and supplement industry—which includes CBD products—is almost wholly unregulated. “The concentrations in products are only approximate, and I don’t know how well they’re tracked,” Szaflarski says. Even if you could absolutely trust a product’s label—and many CBD manufacturers, aware of the current scrutiny on their industry, go to great lengths to assure consumers of the quality of their products—there aren’t a lot of concrete facts when it comes to the type or amount of CBD a person should take for a specific ailment or aim.

    Are there any risks to taking CBD?

    Some studies have turned up evidence—nearly all of it from lab work or animal research—that CBD could potentially affect cell health, fertility, and the breakdown and metabolism of drugs in the liver. “There may be some interactions with pharmaceutical drugs,” Szaflarski says, mentioning drowsiness as one (but not the only) possibility.

    In human studies, including one that found anti-seizure benefits among epileptics, some people have reported diarrhoea, vomiting, fever, and fatigue while taking CBD.

    “But so far, the main risks are that it does seem to have a sedative action, so people could get drowsy,” Grant says. “I have not read about major side effects or bad reactions, so it seems relatively safe as far as we know, but we need systematic research on this.”

    While there are more unknowns than knowns at this point, Grant says he doesn’t discount all the anecdotal CBD reports. “You hear somebody say, ‘Hey, I gave this to myself and my kid and we feel a lot better,’ and we should never dismiss that kind of information,” he says. He points out that many modern medicines were discovered when researchers followed up on exactly this sort of human trial-and-error evidence. “But we still need to do the studies that confirm whether all the good things are true, and how much to give, and how to give it,” he says. “These are all questions that need to be answered.”

    Reference: Vice


Notice: ob_end_flush(): Failed to send buffer of zlib output compression (1) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 5471

Notice: ob_end_flush(): Failed to send buffer of zlib output compression (1) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 5471