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Sativex

Tag: Sativex

  • What’s The Difference Between Non-Intoxicating CBD & THC

    What’s The Difference Between Non-Intoxicating CBD & THC


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    Why is THC intoxicating and CBD is not? How can one cannabinoid alter the mind, & the other not at all?

    When we’re talking about cannabis and euphoria, we’re dealing exclusively with CB1 receptors, which are concentrated in the brain and the central nervous system. The difference between CBD vs. THC comes down to a basic difference in how each one interacts with the cannabinoid 1 (CB1) receptor. THC binds well with CB1 cannabinoid receptors. CBD has a low binding affinity for CB1 receptors. That’s where the two diverge.

    Think of it like an electrical plug connecting to a wall socket. A THC molecule is perfectly shaped to connect with CB1 receptors. When that connection happens, THC activates or stimulates those CB1 receptors. Researchers call THC a CB1 receptor agonist, which means THC works to activate those CB1 receptors.

    THC partially mimics a naturally produced neurotransmitter known as anandamide, aka “the bliss molecule.” Anandamide is an endocannabinoid which activates CB1 receptors. Animal studies have taught us that anandamide can increase appetite and enhance pleasure associated with food consumption, and it’s likely responsible for some of the rewarding effects of exercise (e.g. the “runner’s high”). Anandamide also plays a role in memory, motivation, and pain. THC is a “key” that so closely resembles anandamide that it activates CB1 receptors, allowing it to produce some of those same blissful feelings.

    CBD, by contrast, is not a good fit with CB1 receptors. It’s categorized as an antagonist of CB1 agonists. This means that it doesn’t act directly to activate or suppress CB1 receptors—rather, it acts to suppress the CB1-activating qualities of a cannabinoid like THC. In other words, when you ingest THC and CBD, the THC directly stimulates those CB1 receptors, while the CBD acts as a kind of modulating influence on the THC. As Project CBD co-founder Martin Lee once wrote: “CBD opposes the action of THC at the CB1 receptor, thereby muting the psychoactive effects of THC.”


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    ArticleCBDvsTHC 1024x813 1
    Left: THC directly stimulates the CB1 receptor. This interaction underlies the major psychoactive effects of Cannabis consumption. Right: CBD reduces, or “antagonizes,” THC’s ability to stimulate CB1 receptors. This can decrease some of THC’s effects, especially negative effects like anxiety and short-term memory impairment.

    How does that work in real life? Let’s say you vaporize cannabis flower with 24 percent THC. If that flower has 0.2 percent CBD, the THC is going to excite your CB1 receptors with almost no interference from CBD. You may feel extremely high, and you might also experience some of the less desirable effects of THC, such as a heightened feeling of paranoia. If you consume cannabis with 24 percent THC and 6 percent CBD, though, the CBD should have a dampening effect on the THC. You’ll still feel high, but perhaps not stupefyingly so—and the CBD should help keep the paranoia in check.

    This difference has had profound political implications. As the founders of Project CBD have noted, some have mistakenly labelled THC the “bad cannabinoid” and CBD the “good cannabinoid.” Legislators have passed many “CBD-only” laws in Southern states in an effort to allow patients access to this potent cannabinoid while prohibiting its euphoric sibling. But the pioneering cannabis researcher Raphael Mechoulam has often spoken of the “entourage effect,” the idea that cannabinoids and terpenes may work better together than in isolation. The GW Pharma product Sativex, for example, is a drug approved outside the U.S. for treatment of MS-related muscle spasticity. Sativex contains with a nearly 1:1 CBD-to-THC ratio.

    As researchers learn more about CBD and the role of other cannabinoids and compounds in the treatment of conditions like MS, we may be able to more accurately dose CBD in combination with other cannabis-derived compounds.

    Reference: Leafly

  • What Is CBD? The ‘Miracle’ Cannabis Compound That Doesn’t Get You High

    What Is CBD? The ‘Miracle’ Cannabis Compound That Doesn’t Get You High


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    The cannabis-derived chemical is non-psychoactive and has been hailed as a cure for the disease in early May.

    A federal court declined to protect cannabidiol (CBD), a chemical produced by the cannabis plant, from federal law enforcement, despite widespread belief in its medical value.

    The ruling was contrary to existing evidence, which suggests the chemical is safe and could have multiple important uses as medicine. Many cannabis advocates consider it a miracle medicine, capable of relieving conditions as disparate as depression, arthritis and diabetes.

    The perception of its widespread medical benefits has made the chemical a rallying cry for legalization advocates.

    The first thing to know about CBD is that it is not psychoactive; it doesn’t get people high. The primary psychoactive ingredient in marijuana is tetrahydrocannabinol (THC). But THC is only one of the scores of chemicals – known as cannabinoids – produced by the cannabis plant.

    So far, CBD is the most promising compound from both a marketing and a medical perspective. Many users believe it helps them relax, despite it not being psychoactive, and some believe regular doses help stave off Alzheimer’s and heart disease.


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    Experts: medical marijuana (Cannabis) draws parents to US for their children’s treatments

    While studies have shown CBD to have anti-inflammatory, anti-pain and anti-psychotic properties, it has seen only minimal testing in human clinical trials, where scientists determine what a drug does, how much patients should take, its side effects and so on.

    Despite the government ruling, CBD is widely available over the counter in dispensaries in states where marijuana is legal.

    CBD first came to public attention in a 2013 CNN documentary called Weed. The piece, reported by Dr Sanjay Gupta, featured a little girl in Colorado named Charlotte, who had a rare life-threatening form of epilepsy called Dravet syndrome.

    At age five, Charlotte suffered 300 grand mal seizures a week and was constantly on the brink of a medical emergency. Through online research, Charlotte’s desperate parents heard of treating Dravet with CBD. It was controversial to pursue medical marijuana for such a young patient, but when they gave Charlotte oil extracted from high-CBD cannabis, her seizures stopped almost completely. In honour of her progress, high-CBD cannabis is sometimes known as Charlotte’s Web.

    After Charlotte’s story got out, hundreds of families relocated to Colorado where they could procure CBD for their children, though not all experienced such life-changing results. Instead of moving, other families obtained CBD oil through illegal distribution networks.

    In late June, the US Food and Drug Administration could approve the Epidiolex, a pharmaceutical form of CBD for several severe pediatric seizure disorders. According to data recently published in the New England Journal of Medicine, the drug can reduce seizures by more than 40%. If Epidiolex wins approval it would be the first time the agency approves a drug derived from the marijuana plant. (The FDA has approved synthetic THC to treat chemotherapy-related nausea.)

    Epidiolex was developed by the London-based GW Pharmaceuticals, which grows cannabis on tightly controlled farms in the UK. It embarked on the Epidiolex project in 2013, as anecdotes of CBD’s value as an epilepsy drug began emerging from the US.

    While parents treating their children with CBD had to proceed based on trial and error, like folk medicine, they also had to wonder whether dispensary purchased CBD was professionally manufactured and contained what the package said it did. GW brought a scientific understanding and pharmaceutical-grade manufacturing to this promising compound.

    Fortunately, like THC, CBD appears to be well tolerated; as far as I can tell, there are no recorded incidents of fatal CBD overdoses.

    Since Weed first aired, GW’s stock has climbed 1,500%.

    Should I grow my own weed at home? Here’s what you need to know

    GW’s first drug Sativex, which contains both CBD and THC, is available as a treatment for MS-related spasticity in Canada, Australia, and much of Europe and Latin America. The company is also studying cannabinoid-based drugs as a treatment for autism spectrum disorders, an aggressive brain tumour called glioblastoma, and schizophrenia.

    Other industries, not subject to the strict regulations governing pharmaceuticals are eager to develop their own CBD products, everything from joints and vape pens to skin creams and edibles which may or may not have a valid medical use.

    In Los Angeles, it’s among the latest wellness fads. It can be found in cocktails, and an upscale juice shop will even add a few drops of CBD infused olive oil to a beverage for $3.50.

    Reference: The Guardian


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