Notice: Function _load_textdomain_just_in_time was called incorrectly. Translation loading for the mpc domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 6121

Deprecated: Creation of dynamic property MPC_WC_Grid_Products::$default_atts is deprecated in /var/www/vhosts/mycbds.co.uk/public_html/wp-content/plugins/mpc-massive/shortcodes/mpc_wc_grid_products/mpc_wc_grid_products.php on line 27

Notice: Function _load_textdomain_just_in_time was called incorrectly. Translation loading for the viva-wallet-for-woocommerce domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 6121

Notice: Function WP_Scripts::localize was called incorrectly. The $l10n parameter must be an array. To pass arbitrary data to scripts, use the wp_add_inline_script() function instead. Please see Debugging in WordPress for more information. (This message was added in version 5.7.0.) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 6121

Notice: Function WP_Scripts::localize was called incorrectly. The $l10n parameter must be an array. To pass arbitrary data to scripts, use the wp_add_inline_script() function instead. Please see Debugging in WordPress for more information. (This message was added in version 5.7.0.) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 6121

Notice: Function WP_Scripts::localize was called incorrectly. The $l10n parameter must be an array. To pass arbitrary data to scripts, use the wp_add_inline_script() function instead. Please see Debugging in WordPress for more information. (This message was added in version 5.7.0.) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 6121

Notice: Function WP_Scripts::localize was called incorrectly. The $l10n parameter must be an array. To pass arbitrary data to scripts, use the wp_add_inline_script() function instead. Please see Debugging in WordPress for more information. (This message was added in version 5.7.0.) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 6121
cannabis-derived

Tag: cannabis-derived

  • What’s The Difference Between Non-Intoxicating CBD & THC

    What’s The Difference Between Non-Intoxicating CBD & THC


    Deprecated: mb_convert_encoding(): Handling HTML entities via mbstring is deprecated; use htmlspecialchars, htmlentities, or mb_encode_numericentity/mb_decode_numericentity instead in /var/www/vhosts/mycbds.co.uk/public_html/wp-content/plugins/mpc-massive/shortcodes/mpc_snippets.php on line 2300

    Why is THC intoxicating and CBD is not? How can one cannabinoid alter the mind, & the other not at all?

    When we’re talking about cannabis and euphoria, we’re dealing exclusively with CB1 receptors, which are concentrated in the brain and the central nervous system. The difference between CBD vs. THC comes down to a basic difference in how each one interacts with the cannabinoid 1 (CB1) receptor. THC binds well with CB1 cannabinoid receptors. CBD has a low binding affinity for CB1 receptors. That’s where the two diverge.

    Think of it like an electrical plug connecting to a wall socket. A THC molecule is perfectly shaped to connect with CB1 receptors. When that connection happens, THC activates or stimulates those CB1 receptors. Researchers call THC a CB1 receptor agonist, which means THC works to activate those CB1 receptors.

    THC partially mimics a naturally produced neurotransmitter known as anandamide, aka “the bliss molecule.” Anandamide is an endocannabinoid which activates CB1 receptors. Animal studies have taught us that anandamide can increase appetite and enhance pleasure associated with food consumption, and it’s likely responsible for some of the rewarding effects of exercise (e.g. the “runner’s high”). Anandamide also plays a role in memory, motivation, and pain. THC is a “key” that so closely resembles anandamide that it activates CB1 receptors, allowing it to produce some of those same blissful feelings.

    CBD, by contrast, is not a good fit with CB1 receptors. It’s categorized as an antagonist of CB1 agonists. This means that it doesn’t act directly to activate or suppress CB1 receptors—rather, it acts to suppress the CB1-activating qualities of a cannabinoid like THC. In other words, when you ingest THC and CBD, the THC directly stimulates those CB1 receptors, while the CBD acts as a kind of modulating influence on the THC. As Project CBD co-founder Martin Lee once wrote: “CBD opposes the action of THC at the CB1 receptor, thereby muting the psychoactive effects of THC.”


    Deprecated: mb_convert_encoding(): Handling HTML entities via mbstring is deprecated; use htmlspecialchars, htmlentities, or mb_encode_numericentity/mb_decode_numericentity instead in /var/www/vhosts/mycbds.co.uk/public_html/wp-content/plugins/mpc-massive/shortcodes/mpc_snippets.php on line 2300
    ArticleCBDvsTHC 1024x813 1
    Left: THC directly stimulates the CB1 receptor. This interaction underlies the major psychoactive effects of Cannabis consumption. Right: CBD reduces, or “antagonizes,” THC’s ability to stimulate CB1 receptors. This can decrease some of THC’s effects, especially negative effects like anxiety and short-term memory impairment.

    How does that work in real life? Let’s say you vaporize cannabis flower with 24 percent THC. If that flower has 0.2 percent CBD, the THC is going to excite your CB1 receptors with almost no interference from CBD. You may feel extremely high, and you might also experience some of the less desirable effects of THC, such as a heightened feeling of paranoia. If you consume cannabis with 24 percent THC and 6 percent CBD, though, the CBD should have a dampening effect on the THC. You’ll still feel high, but perhaps not stupefyingly so—and the CBD should help keep the paranoia in check.

    This difference has had profound political implications. As the founders of Project CBD have noted, some have mistakenly labelled THC the “bad cannabinoid” and CBD the “good cannabinoid.” Legislators have passed many “CBD-only” laws in Southern states in an effort to allow patients access to this potent cannabinoid while prohibiting its euphoric sibling. But the pioneering cannabis researcher Raphael Mechoulam has often spoken of the “entourage effect,” the idea that cannabinoids and terpenes may work better together than in isolation. The GW Pharma product Sativex, for example, is a drug approved outside the U.S. for treatment of MS-related muscle spasticity. Sativex contains with a nearly 1:1 CBD-to-THC ratio.

    As researchers learn more about CBD and the role of other cannabinoids and compounds in the treatment of conditions like MS, we may be able to more accurately dose CBD in combination with other cannabis-derived compounds.

    Reference: Leafly


Notice: ob_end_flush(): Failed to send buffer of zlib output compression (1) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 5471

Notice: ob_end_flush(): Failed to send buffer of zlib output compression (1) in /var/www/vhosts/mycbds.co.uk/public_html/wp-includes/functions.php on line 5471